In the new generations of increase in solubility of the pharmaceutical formulations different problems are raised. The bioavailability and absorption of water soluble phytoconstituents is unpredictable due to poor solubility of these constituents in gastrointestinal tract. This can be overcome by a novel drug delivery system known as phytosome technology in which water soluble phytoconstituents are enabled to react with phospholipids. For better and improved bioavailability, natural phytoconstituents must have a good balance between hydrophilicity which helps in dissolution in gastrointestinal fluids and hydrophobicity which helps to cross lipid rich cell membranes can be achieved through phytosome technology. In ancient times phytomedicines are used as a health maintenance it is a complex mixture prepared from plants. Phytosomes show better pharmacokinetic and pharmacodynamic profile than conventional herbal extracts.
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